The BCAC database includes data on more than 400,000 individuals. This includes:
- Core demographic data
- Data on diagnosis, pathology, treatment and outcome for breast cancer patients
- Data on breast cancer risk factors
- Mammographic density data
- Genetic data
Genotype Data
The BCAC database currently includes genotype data from two large genotyping arrays, iCOGS and OncoArray, together with data on a smaller number of genetic markers genotyped in eleven phases. Data from the Confluence array is currently being generated.
Germline Sequence Data
The BCAC database also includes both whole genome and targeted sequence data from the BRIDGES project, the Perspective I&I project and the B-CAST project.
Tumour Data
The BCAC holds targeted sequencing data ~10,000 breast tumours and image data from tissue microarrays on ~30,000 tumours, generated by the B-CAST project.
Data Access
Access to BCAC data is available:
1. Summary data
- Summary results from the GWAS (iCOGS & OncoArray), and, sequencing (BRIDGES) projects are publicly available.
2. Individual level BCAC data
- Access to individual level BCAC data is governed by a Data Access Coordinating Committee (DACC). To request access to individual level BCAC data, please follow the procedure below:
- (a) Download the concept analysis application form, and return the completed form to the BCAC Data Access Coordination Committee (DACC). The DACC review all submitted applications three times a year and will be in contact with the concept proposer once this review process has taken place. [Note: The BCAC data dictionary can be downloaded here].
- (b) If the DACC approves the concept analysis: (i) there is a one month period for BCAC PIs to opt-out of any analysis for their study samples, (ii) a non-negotiable DTA must be signed by the concept proposer and their institution, (iii) a fee is payable for the data access. Please also refer to the concept analysis application form for more details.
- (c) Once the above steps have been completed, the requested data will be sent to the concept proposer, with details of the BCAC authorship/funding/acknowledgment requirements for any publications resulting from the data analyses.
- If you have any queries, please contact the BCAC Coordinator.