Welcome to CIMBA
The Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) was established in 2005. It was formed by a collaborative group of researchers working on genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers. Since then CIMBA has extended its research into the effects of other cancer susceptibility genes e.g. ATM, PALB2, TP53 among others.
The aim of CIMBA is to provide sufficient sample sizes to allow large scale studies in order to evaluate reliably the effects of genetic modifiers.
Currently, the Consortium consists of >85 different study groups, incorporating sites from Europe, North and South America, Australia, Asia and Africa. We have phenotype data for ~90,000 female and male BRCA1 and BRCA2 mutation carriers and to date ~58,000 have been genotyped for CIMBA projects.
CIMBA Coordination & Funding
Coordination of CIMBA is through the University of Cambridge and the QIMR Berghofer Medical Research Institute and funded by Cancer Research UK (CRUK), the National Health and Medical Research Council of Australia (NHMRC) and the Gray Foundation.
CIMBA is supported by funding from Cancer Research UK programme grant (PPRPGM-Nov20\100002): CanRisk: Personalising cancer risk prediction for prevention and early detection.