The primary aims of this study are:
- To continue recruiting to the cohort of BRCA1/2 breast/ovarian cancer gene mutation carriers, and their relatives, identified through clinical genetics centres in the UK,
- To recruit from families with other mutations identified as high-risk
- To obtain self-reported information, by questionnaire, on affected (with cancer) and unaffected mutation carriers, in order to determine lifestyle factors which may modify risk.
- To identify those who can be followed up after recruitment to determine their cancer risks and the effect of different interventions (mastectomy and oophorectomy) on that risk
- To collect serial blood samples from participants to evaluate
- genetic variants that may modify the risk of cancer associated with the mutation
- blood markers and their potential to detect cancer earlier
We hope that the information obtained from this study, combined with data obtained from similar studies in other countries, on cancer incidence rates and modifying factors will be of critical importance to the current and future management of mutation carriers.