Pre-iCOGS genotyping in CIMBA comprised the following:
1. Genotyping on the Exome array
- BRCA1: >247,000 SNPs genotyped in 2,079 carriers
2. GWAS in BRCA1 mutation carriers
- Stage 1: >500,000 SNPs genotyped in 2727 carriers
- Stage 2: 89 SNPs genotyped in 5,986 carriers
3. GWAS in BRCA2 mutation carriers
- Stage 1: >500,000 SNPs genotyped in 1703 carriers
- Stage 2: 85 SNPs genotyped in 2486 carriers
4. Candidate SNP studies for >100 SNPs