Professor of Cancer Risk Prediction
Tel. +44 (0)1223 748630
Email: aca20@cam.ac.uk
Background
Professor Antoniou studied Actuarial Science at the London School of Economics and Political Science, followed by an MPhil in Mathematical Statistics at the University of Cambridge before completing his PhD in Genetic Epidemiology at Cambridge. He was awarded a CRUK Senior Cancer Research Fellowship in 2009. In 2013, he was appointed Reader and, in 2017, Professor of Cancer Risk Prediction. He was appointed director of the CRUK Cancer Data Driven Detection (CD3) national strategic initiative in 2023.
Research
Professor Antoniou’s research focuses on the following areas:
- Improving cancer risk stratification by developing novel multifactorial algorithms using state-of-the-art analytical techniques, and leveraging epidemiological, genomic, clinical and demographic data from large-scale, diverse sources, including international consortia, population cohorts and linked electronic health records.
- Identifying and characterising novel cancer risk factors, including genetic markers, symptoms, biomarkers and imaging factors.
- The characterisation of cancer risks for genetically susceptible individuals, such as those carrying mutations in the BRCA1, BRCA2, PALB2, RAD51C and RAD51D genes.
- Developing user-friendly tools to facilitate personalised risk prediction in routine clinical practice.
- Operationalising multifactorial cancer risk assessment in routine clinical practice.
Specific ongoing programmes of work and projects include:
Cancer Data Driven Detection (CD3) Initiative (Director): CD3 is a multidisciplinary and multi-institutional strategic national research initiative dedicated to using data to revolutionise our understanding of cancer risk and enable early interception of cancers. It is major, multi-million-pound flagship investment funded through a strategic programme award from Cancer Research UK, in partnership with Health Data Research UK (HDR UK), the Economic and Social Research Council’s Administrative Data Research UK programme (ADR UK), the National Institute for Health and Care Research (NIHR) and the Engineering and Physical Sciences Research Council (EPSRC).
CanRisk a CRUK funded programme on “Personalising cancer risk prediction for prevention and early detection”. This includes the development of the BOADICEA risk prediction algorithm which can be used for predicting the risk of developing breast or ovarian cancer and its implementation in the CanRisk tool.
Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA): investigation of genetic and other modifiers of breast, ovarian and prostate cancer risks for BRCA1 and BRCA2 mutation carriers.
EMBRACE: Epidemiological study of mutation carriers in BRCA1, BRCA2 and other cancer susceptibility genes EMBRACE
CANGENE-CANVAR: data resources, clinical and educational tools to leverage cancer susceptibility genetics for prevention and early detection of cancer
RREDD-EHR: Real-world risk-stratified early detection and diagnosis using linked electronic health records data.
Teaching
Since 2010 Professor Antoniou has lectured on the MPhil in Epidemiology and MPhil in Population Health Sciences. He has been a member of the MPhil Admissions and Management committees since 2013. He served as the Academic Course Director for the MPhil in Epidemiology between 2016-2021 and as the academic theme lead for the epidemiology track of the MPhil in Population Health Sciences between 2021-2023.
Publications
For a full list of Publications, please go to: Professor Antonis C Antoniou - Google Scholar