Breast Cancer Survival Analysis (Hoppe R, Winter S et al 2025)
- The summary results from this paper can be downloaded here.
In downloading the data, you are accepting the terms and conditions as set out below.
The results files provide summary survival association statistics for the analyses described in Hoppe R, Winter S et al (NPJ Breast Cancer, 2025). Summary survival association statistics are provided for aromatase inhibitor (AI)-treated patients of the discovery cohort as well as for anastrozole- and letrozole-treated subgroups. Survival endpoints were overall survival, distant relapse-free survival, and relapse-free survival (primary endpoints). Summary statistics for AI-treated patients are also available for analyses of the secondary endpoints breast cancer-specific survival, distant recurrence-free interval, and recurrence-free interval.
Description of files and field names in the results files are also included in the download.
Acknowledgements
You are free to use make use of this resource in publications.
If you do so, please cite Hoppe R, Winter S et al (NPJ Breast Cancer, 2025) and please acknowledge the following:
BCAC is supported by Cancer Research UK grant: PPRPGM-Nov20\100002 and by core funding from the NIHR Cambridge Biomedical Research Centre (NIHR203312). Additional funding for BCAC is provided by the Confluence project which is funded with intramural funds from the National Cancer Institute Intramural Research Program, National Institutes of Health, and the PERSPECTIVE I&I project, funded by the Government of Canada through Genome Canada and the Canadian Institutes of Health Research, the Ministère de l’Économie et de l'Innovation du Québec through Genome Québec and grant PSR-SIIRI-701, the Quebec Breast Cancer Foundation.
The breast cancer genome-wide association analyses were also supported by the National Institutes of Health (U19 CA148065, X01HG007492), Cancer Research UK (C1287/A10118, C1287/A16563, C1287/A10710) and The European Union (HEALTH-F2-2009-223175 and H2020 633784 and 634935). All studies and funders are listed in Hoppe, Winter et al (NPJ Breast Cancer, 2025).
Disclaimer Use of Survival Estimates
The summary estimates of the discovery analysis described in Hoppe R, Winter S et al (NPJ Breast Cancer, 2025) are based on BCAC iCOGS and Oncoarray data. Please refer to this paper when using these survival summary results. The estimates were based on follow-up data available at the time of the analyses (BCAC version 12) and on imputed genotype data using the 1000 Genomes Project as a reference. Please realise that the data online are not the most recent and estimates may have changed in analyses using updated follow-up data and/or another reference.
Terms of Use
The sample size and precision of the data presented should preclude identification of any individual subject. However, in downloading these data, you undertake not to attempt to identify individual subjects and not to repost these data to a third-party website.