The core components of the study include the following:
- baseline epidemiological questionnaire; recruit self-reports lifestyle, screening and medical information
- blood samples; for researching genotypes and other blood factors relating to risk and cancer
- pedigree; for family history information obtained from the clinics
- cancer pathology and clinical details/treatments; obtained from medical records
- tumour tissue
- follow up, after recruitment, to include-
- questionnaires & blood at 2, 5 and 10 years after recruitment
- Additional intervening blood samples for eligible participants in the Early Detection program
- NHS Digital reports for events, including those after 10 years