Submitted by Manjeet Bolla on Thu, 13/03/2025 - 10:10
In a paper published in the American Journal of Human Genetics, CCGE researchers used data from UK Biobank to evaluate the contribution of coding variants to the heritability of 11 cancer types. The results show that gene variants make the largest contribution for ovarian cancer, followed by endometrial, pancreatic and breast cancer. The analyses demonstrate significant clustering of cancer types, including a near-complete overlap in susceptibility genes for breast, ovarian, prostate, and pancreatic cancer. The results also highlight several potential new susceptibility genes including the DNA repair gene NHEJ1.
See: https://www.cell.com/ajhg/fulltext/S0002-9297(25)00060-6